• Internal medicine · Oct 2020

    Case Reports

    Successful Recovery from COVID-19-associated Acute Respiratory Failure with Polymyxin B-immobilized Fiber Column-direct Hemoperfusion.

    • Yusaku Kusaba, Shinyu Izumi, Jin Takasaki, Manabu Suzuki, Daisuke Katagiri, Takashi Katsuno, Shuichiro Matsumoto, Keita Sakamoto, Masao Hashimoto, Norio Ohmagari, Harutaka Katano, Tadaki Suzuki, Masayuki Hojo, and Haruhito Sugiyama.
    • Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan.
    • Intern. Med. 2020 Oct 1; 59 (19): 2405-2408.

    AbstractAn 83-year-old man was hospitalized for coronavirus disease 2019 (COVID-19) after a 10-day history of a persistent fever. Chest computed tomography showed extensive non-segmental ground glass opacity. Despite the initiation of lopinavir and ritonavir, respiratory failure progressed. Two days of polymyxin B-immobilized fiber column-direct hemoperfusion (PMX-DHP) with adjunctive corticosteroid prevented his respiratory condition from worsening. For rapidly progressive COVID-19 cases, the early use of PMX-DHP may avoid the need for mechanical ventilation by suppressing local inflammation of the lung.

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