• Marija Gamulin, Eric Nham, Deni Rkman, Zrna Antunac Golubić, and Robert Likić.
• Robert Likic, University Hospital Centre Zagreb, Department of Internal Medicine Unit of Clinical Pharmacology, Kispaticeva 12, 10000 Zagreb, Croatia, robert.likic@mef.hr.
• Croat. Med. J. 2020 Aug 31; 61 (4): 326-332.

AimTo assess diseases outcomes and tolerability of real-life second-line nivolumab in a series of metastatic renal cell carcinoma (mRCC) patients.MethodsThis retrospective chart review involved prospectively monitored patients (named patient program) treated with second-line nivolumab for mRCC at the University Hospital Centre Zagreb from February 2016 to March 2018.ResultsThe study enrolled 30 patients, 5 of whom (16.7%) had a complete response. The mean ± standard deviation therapeutic response time to nivolumab treatment was 14.07 ± 8.92 months, with a minimum treatment duration of 2 months and a maximum of 24 months. The median duration of therapy was 17 months (mean: 15.8 months; range: 3-24 months), and 50% (n=15/30) of patients remained alive at the end of follow up. The most common adverse events associated with nivolumab were fatigue (26.67%; n=8/30), anemia (10.0%; n=3/30), adrenal insufficiency (6.67%; n=2/30: G1=1, G2=1), grade 2 pneumonitis (6.67%; n=2/30), grade 2 neuropathy (6.67%; n=2/30), rash (6.67%; n = 2/30: G1=1, G2=1), and hepatitis (3.33%; n=1/30).ConclusionThe present study indicates acceptable patient responses and tolerability of nivolumab in mRCC.

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