• Javad Sharifi-Rad, Célia F Rodrigues, Zorica Stojanović-Radić, Marina Dimitrijević, Ana Aleksić, Katarzyna Neffe-Skocińska, Dorota Zielińska, Danuta Kołożyn-Krajewska, Bahare Salehi, Selvaraj Milton Prabu, Francine Schutz, Anca Oana Docea, Natália Martins, and Daniela Calina.
• Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran.
• Medicina (Kaunas). 2020 Aug 27; 56 (9).

AbstractThe positive impact of probiotic strains on human health has become more evident than ever before. Often delivered through food, dietary products, supplements, and drugs, different legislations for safety and efficacy issues have been prepared. Furthermore, regulatory agencies have addressed various approaches toward these products, whether they authorize claims mentioning a disease's diagnosis, prevention, or treatment. Due to the diversity of bacteria and yeast strains, strict approaches have been designed to assess for side effects and post-market surveillance. One of the most essential delivery systems of probiotics is within food, due to the great beneficial health effects of this system compared to pharmaceutical products and also due to the increasing importance of food and nutrition. Modern lifestyle or various diseases lead to an imbalance of the intestinal flora. Nonetheless, as the amount of probiotic use needs accurate calculations, different factors should also be taken into consideration. One of the novelties of this review is the presentation of the beneficial effects of the administration of probiotics as a potential adjuvant therapy in COVID-19. Thus, this paper provides an integrative overview of different aspects of probiotics, from human health care applications to safety, quality, and control.

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