• Biomarkers in medicine · Dec 2018

    Clinical Trial

    High-sensitivity troponin T is a prognostic marker of hemodynamic instability in patients undergoing valve surgery.

    • Piotr Duchnowski, Tomasz Hryniewiecki, Małgorzata Koźma, Kuśmierczyk Mariusz, and Szymański Piotr.
    • Department of Acquired Cardiac Defects, Institute of Cardiology, Warsaw, Poland.
    • Biomark Med. 2018 Dec 1; 12 (12): 1303-1309.

    AimThe usefulness of high-sensitivity troponin T (hs-TnT) as a predictor of perioperative hemodynamic instability is currently unknown.MethodsA prospective study was conducted on a group of 708 consecutive patients with significant valvular heart disease that underwent elective valve surgery. The primary end point was postoperative hemodynamic instability. The secondary end point was death from all causes in patients with perioperative hemodynamic instability.ResultsThe postoperative hemodynamic instability occurred in 131 patients. At multivariate analysis hs-TnT measured immediately after surgery and New York Heart Association classes remained independent predictors of the primary end point. Age and hs-TnT measured immediately after surgery were associated with an increased risk of death.ConclusionElevated postoperative hs-TnT was associated with a higher risk of postoperative hemodynamic instability and death.

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