• J Pain Symptom Manage · Mar 2012

    Case Reports

    Corticosteroid rotation to alleviate dexamethasone-induced hiccup: a case series at a single institution.

    • Jung Hun Kang, David Hui, Moon Jin Kim, Hoon Gu Kim, Myoung Hee Kang, Gyeong-Won Lee, and Eduardo Bruera.
    • Department of Palliative Care and Rehabilitation Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. jkang2@mdanderson.org
    • J Pain Symptom Manage. 2012 Mar 1; 43 (3): 625-30.

    AbstractDexamethasone, one of the key medications for the prevention of chemotherapy-induced nausea and vomiting (CINV), may cause hiccups as an adverse effect. In this case series, we present five patients who developed hiccups after receiving dexamethasone for CINV. We successfully switched dexamethasone to an equipotent dosage of either methylprednisolone or prednisolone, which resolved the hiccups while maintaining adequate control of CINV. This was achieved without changing the rest of the antiemetic regimen, chemotherapy doses, or the use of other medications such as baclofen, haloperidol, and metoclopramide for hiccups. Further studies on switching dexamethasone to alternative corticosteroids in patients developing hiccups after administration of dexamethasone are warranted.Copyright © 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

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