• Int. J. Clin. Pract. · Sep 2013

    Case Reports

    Baclofen in the treatment of persistent hiccup: a case series.

    • A Mirijello, G Addolorato, C D'Angelo, A Ferrulli, G Vassallo, M Antonelli, L Leggio, and R Landolfi.
    • Department of Internal Medicine, Catholic University of Rome, Italy.
    • Int. J. Clin. Pract. 2013 Sep 1; 67 (9): 918-21.

    BackgroundPersistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments.AimTo test baclofen administration for the treatment of persistent hiccup.MethodWe report a series of seven patients affected by persistent hiccup successfully treated with baclofen.ResultsHiccup stopped in all patients after a single administration of the drug.ConclusionsBaclofen is a GABA(B) receptor agonist. It is conceivable that the reduction of dopamine release by GABA(B) receptor stimulation is able to interrupt hiccup's reflex arc.© 2013 John Wiley & Sons Ltd.

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