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Frontiers in immunology · Jan 2019
ReviewB Cell Dysfunction Associated With Aging and Autoimmune Diseases.
- Shiliang Ma, Chengwei Wang, Xinru Mao, and Yi Hao.
- Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
- Front Immunol. 2019 Jan 1; 10: 318.
AbstractImpaired humoral responses, as well as an increased propensity for autoimmunity, play an important role in the development of immune system dysfunction associated with aging. Accumulation of a subset of atypical B cells, termed age-associated B cells (ABCs), is one of the key age-related changes in B cell compartments. ABCs are characterized by their distinct phenotypes, gene expression profiles, special survival requirements, variations in B cell receptor repertoires, and unique functions. Here, we summarize recent progress in the knowledge base related to the features of ABCs, their potential role in immune senescence, and their relationship with autoimmune diseases.
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