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Sheng Li Ke Xue Jin Zhan · Oct 2004
Review[Inhibitory proteins against axon regeneration in the central nervous system].
- Jian-Guo Hu, Pei-Hua Lu, and Xiao-min Xu.
- Department of Neurobiology, Shanghai Second Medical University, Shanghai.
- Sheng Li Ke Xue Jin Zhan. 2004 Oct 1; 35 (4): 311-4.
AbstractGrowth inhibition in the central nervous system (CNS) is a majar barrier to axon regeneration. To date, three inhibitory proteins of oligodendrocytes/myelin have been identified: myelin associated glycoprotein ( MAG) , Nogo-A and oligodendrocyte-myelin glycoprotein (OMgp). Recently, findings indicate that three distinct myelin components inhibit axon growth by binding a common receptor, the Nogo 66 receptor (NgR). These novel findings lead to further understanding of the barriers to axon regeneration after injury in the CNS and provide new avenues to explore the new theraphy strategy for the CNS injury.
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