• A Garnier-Crussard, V Desestret, F Cotton, G Chételat, and P Krolak-Salmon.
• Centre mémoire ressource et recherche de Lyon (CMRR), hôpital des Charpennes, institut du vieillissement I-Vie, hospices civils de Lyon, 69002 Lyon, France; Université Claude-Bernard Lyon 1, 69008 Lyon, France; Université de Normandie, Unicaen, Inserm, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", institut Blood-and-Brain @ Caen-Normandie, Cyceron, 14000 Caen, France. Electronic address: antoine.garnier-crussard@chu-lyon.fr.
• Rev Med Interne. 2020 Jul 1; 41 (7): 475-484.

AbstractWhite matter hyperintensities (WMH), also known as leukoaraïosis are very common neuroradiological manifestations in the elderly. The main risk factors for WMH are age and high blood pressure. The vascular origin of these lesions is classically accepted and WMH are considered as one feature of the small vessel disease. WMH may be associated with clinical symptoms, depending notably on their importance according to age. They are associated with increased mortality, strokes and changes in cognition with a higher risk of dementia (vascular dementia or Alzheimer's disease). Modification of vascular risk factors could have a beneficial effect, but few evidences from controlled trials are available.Copyright © 2020 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

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