• Ann Vasc Surg · Jul 2017

    The Protective Effect of Curcumin on a Spinal Cord Ischemia-Reperfusion Injury Model.

    • İlker Akar, İlker İnce, Akgül Arici, İsmail Benli, Cemal Aslan, Sefa Şenol, Osman Demir, Fatih Altunkas, Nuray Altındeger, and Ali Akbas.
    • Deparment of Cardiovascular Surgery, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey. Electronic address: ilkerakar16@yahoo.com.
    • Ann Vasc Surg. 2017 Jul 1; 42: 285-292.

    BackgroundThe purpose of this study is to investigate the neurological, biochemical, and histopathologic effects of both the acute and maintenance treatment of curcumin on an experimental spinal cord ischemia-reperfusion injury model in rats.MethodsThe animals were randomly divided into 4 groups: (1) Sham, (2) ischemia-reperfusion (IR), (3) curcumin, and (4) solvent. Spinal cord ischemia was induced by clamping the aorta with minivascular clamps at a position just below the left renal artery and just proximal to the aortic bifurcation for 45 min. After 72 hr of reperfusion, neurological function was evaluated with a modified Tarlov score. In spinal cords, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), and nitric oxide (NO) levels were detected biochemically. Immunohistochemical staining was performed by antibodies against interleukin-6 (IL-6) and myeloperoxidase. Histopathologic changes were examined with hematoxylin and eosin staining.ResultsAlthough MDA tissue levels were elevated significantly in the IR group compared with the sham group, SOD and GPx levels decreased. After the administration of curcumin, MDA levels in the spinal cord decreased, and SOD and GPx levels increased. Those changes were statistically significant. There was no significance at NO levels. Among all groups, there was no difference in IL-6 and myeloperoxidase immunostaining. Histopathological analysis showed that histopathological changes in the IR group were improved by curcumin treatment. In the curcumin group, neurological outcome scores were significantly better statistically when compared with the IR group.ConclusionWe believe that curcumin possesses antioxidant, antiproliferative, and anticarcinogenic properties and may be an effective drug for the prevention of spinal cord IR injury in light of the neurologic, biochemical, and histopathological data of this study and published scientific literature.Copyright © 2017 Elsevier Inc. All rights reserved.

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