• Wanda M Popescu, Robert Bell, Andrew J Duffy, Karol H Katz, and Albert C Perrino.
• Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520-8051, USA. Wanda.Popescu@yale.edu
• J. Cardiothorac. Vasc. Anesth.. 2011 Dec 1;25(6):943-9.

ObjectiveGiven the propensity for heart disease in obese patients, the authors investigated the effects of pneumoperitoneum on cardiac performance.DesignA pilot observational intraoperative study.SettingA single-center university hospital.ParticipantsPatients undergoing laparoscopic gastric bypass surgery.InterventionsAbdominal insufflation.Measurements And ResultsHemodynamic, respiratory, and echocardiographic data were collected at 4 epochs: (1) baseline after the induction of anesthesia, (2) after abdominal insufflation in supine position, (3) after abdominal insufflation in the reverse Trendelenburg (RT) position, and (4) after desufflation in RT position. At epoch 1, 3 of 13 patients manifested systolic dysfunction (SD), 5 of 13 patients exhibited diastolic dysfunction (DD) according to transmitral flow (TMF) Doppler criteria, and 4 of 8 patients according to Doppler tissue imaging (DTI) criteria. With pneumoperitoneum, the total systemic resistance increased to values of 142% from baseline (p < 0.05). Compared with baseline, stroke volume decreased by 25%, cardiac output by 35%, and fractional area change by 13% (p < 0.05). Mean arterial blood pressure and heart rate remained stable. Additionally, new-onset DD manifested in 1 of 8 patients according to TMF criteria and in 3 of 4 patients according to DTI criteria. Desufflation of the abdomen reverted the diastolic function to baseline in all but 1 patient.ConclusionThe study data revealed that surgical pneumoperitoneum used in patients with clinically severe obesity resulted in the deterioration of cardiac performance including the development of new-onset DD. These patients, despite their relative young age and without a history of heart failure or coronary artery disease, displayed a cardiovascular profile during laparoscopic surgery similar to that seen in patients with significant heart disease.Copyright © 2011 Elsevier Inc. All rights reserved.

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