• Chun-Yang Zhang, Bin Yang, Dong-Mei Li, Qiu-Yan Shi, Hong Li, Yan-Ling Li, and Cui-Lan Wang.
• Medicine (Baltimore). 2020 Sep 4; 99 (36): e21958.

IntroductionWake up stroke starts in sleep and is a more common form of ischemic stroke. At present, it is still controversial whether wake up stroke can be treated with thrombolytic therapy. Therefore, this study will combine imaging techniques to assess the onset time of wake up stroke patients, and to analyze the imaging characteristics of wake up stroke patients and patients suitable for thrombolytic therapy within the time window.Methods/DesignThis study will be a single-blinded, randomized controlled trial with 2 parallel groups. It will be conducted at North China University of science and technology affiliated hospital.DiscussionThere is no consistent conclusion about the pathogenesis of wake up stroke. Wake up stroke is more likely to manifest as small vessel disease. The incidence of wake up stroke patients is relatively high, and the effectiveness and safety of intravenous thrombolysis under the guidance of multimode imaging therapy in wake up stroke need to be further explored by prospective, large-scale studies.Trial RegistrationClinicalTrials.gov, ChiCTR2000034402, Registered on 05 July 2020.

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