• Renyan Zhang, Xing Dong, Junyao Wang, Ying Guo, and Yong Dai.
• School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
• Medicine (Baltimore). 2020 Sep 4; 99 (36): e22044e22044.

BackgroundMalaria remains a global health threat for centuries. In recent years, a rising resistance of Plasmodium falciparum to current standard artemisinin-based combination therapies (ACTs) leads to increasing treatment failures and requires for optimized treatment. Here, we intend to make a systematic review and meta-analysis of optimizing treatment for malaria, so as to find a potential optimal treatment.MethodsWe will search electronic databases: the Cochrane Infectious Diseases Group (CIDG) Specialized Register, the Cochrane Central Register of Controlled Trials (CEN-TRAL), PubMed, Embase, Web of Science from their inception to 1 July, 2020. We will also search International Clinical Trials Registry Platform (ICTRP) and ClinicalTrials.gov, and contact with authors when necessary. Two authors will independently collect and select data, and the statistical analyses will be conducted by Revman V.5.3 software.ResultsWe will evaluate efficacy and safety of modified ACTs for uncomplicate malaria, comparing with standard ACTs in all eligible clinical studies.ConclusionIn this study, we will offer clinical evidence for optimizing treatment for malaria.Registration NumberINPLASY202070115.

33 keywords...

hide…