• Nadine Reckord, Michael Behnes, Michèle Natale, Agnibh Mukherji, Jonas Rusnak, Uzair Ansari, Siegfried Lang, Ursula Hoffmann, Martin Borggrefe, Thomas Henzler, Michael Neumaier, Maximilian T Kittel, Kambis Mashayekhi, Thomas Bertsch, and Ibrahim Akin.
• First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
• Curr Pharm Biotechnol. 2017 Jan 1; 18 (6): 508-515.

BackgroundThis study evaluates the association between high sensitivity troponin I (hsTnI) and T (hsTnT) in patients with suspected stable Coronary Artery Disease (CAD) undergoing Coronary Computed Tomography Angiography (CCTA).MethodsPatients undergoing CCTA were enrolled prospectively. CCTA was indicated in patients with angina and a low to intermediate pre-test probability for CAD during routine clinical care. Blood samples were taken at the time of CCTA to measure cardiac biomarkers.ResultsA total of 99 patients were enrolled with 43 % revealing no CAD, 30 % with non-obstructive and 26 % with obstructive CAD. Out of these, 61 % had single-vessel and 39 % had multi-vessel CAD. Both hsTnI and hsTnT levels increased significantly according to the presence and extent of CAD (p = 0.0001) and were able to discriminate the presence of both obstructive (AUC range: 0.775 - 0.785; p = 0.0001) and multi-vessel CAD (AUC range: 0.740 - 0.749; p = 0.01). In multivariate logistic regression models adjusted for cardiovascular risk factors and NT-proBNP, both hsTn were still associated significantly with obstructive CAD (range of odds ratios (OR): 8.3-32.3; p < 0.02).DiscussionThis study shows that high sensitivity troponin I and T reflect the presence and extent of CAD being diagnosed by CCTA in patients with a low to intermediate pretest probability for CAD.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

30 keywords...

hide…