• Critical care clinics · Oct 2020

    Review

    Impact of the Opioid Epidemic.

    • Eric J Lavonas and Cameron Dezfulian.
    • Department of Emergency Medicine, Rocky Mountain Poison and Drug Safety, Denver Health, 777 Bannock Street, MC 0108, Denver, CO 80238, USA; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address: eric.lavonas@dhha.org.
    • Crit Care Clin. 2020 Oct 1; 36 (4): 753-769.

    AbstractIn recent years the prescription opioid overdose epidemic has decreased, but has been more than offset by increases in overdose caused by fentanyl and fentanyl analogues. Opioid overdose patients should receive naloxone if they have significant respiratory depression and/or loss of protective airway reflexes. Patients who receive naloxone should be observed for recurrent opioid effects. Patients with opioid overdose may be admitted to the intensive care unit for naloxone infusions, treatment of noncardiogenic pulmonary edema, autonomic instability, or sequelae of hypoxia-ischemia or cardiac arrest. Primary and secondary prevention are important to reduce the number of people with life-threatening opioid overdose.Copyright © 2020 Elsevier Inc. All rights reserved.

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