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Case Reports
Nintedanib in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation.
- Wenjiao Tang, Ting Yu, Tian Dong, Ting Liu, and Jie Ji.
- Department of Hematology, Sichuan University West China Hospital, Chengdu, China.
- Chest. 2020 Sep 1; 158 (3): e89-e91.
AbstractBronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplantation (allo-HCT) usually confers poor prognosis and high mortality. Currently, therapeutic options are limited. Here we report an 18-year-old man with acute myeloid leukemia developed BOS after allo-HCT and responded poorly to inhaled corticosteroids and short-acting β-agonist, azithromycin, montelukast, and immunosuppressants. Then he started nintedanib treatment, and the symptoms of nonproductive cough and dyspnea were alleviated gradually. His pulmonary function test revealed increased FEV1 compared to baseline.Copyright © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
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