• Medicina clinica · Nov 2019

    Impact of intestinal microbiota in patients with heart failure: A systematic review.

    • Francesc Formiga, Cristiana Isabel Ferreira Teles, and David Chivite.
    • Servicio de Medicina Interna, Hospital Universitario de Bellvitge, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, España. Electronic address: fformiga@bellvitgehospital.cat.
    • Med Clin (Barc). 2019 Nov 29; 153 (10): 402-409.

    AbstractHeart failure (HF) is a chronic disease with significant morbidity and mortality. Substantial haemodynamic changes such as hypoperfusion and intestinal congestion can alter the composition of the intestinal microbiota in patients with HF. The aim of this systematic review is to evaluate the influence of bowel function in patients with HF and the possible role of the intestinal microbiota in the development and evolution of the latter. Eleven studies were included in the review. These studies seem to confirm that HF patients present with substantial abnormalities in the composition of their intestinal microbiota. Trimethylamine N-oxide is identified as a key mediator between the alterations in the intestinal microbiota and HF and correlates with worse prognosis in HF patients. In conclusion, patients with HF present with frequent abnormalities in the characteristics of their intestinal microbiota, which may play a role in the prognosis of the disease.Copyright © 2019 Elsevier España, S.L.U. All rights reserved.

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