• Yue-Nan Ni, Yan-Mei Wang, Bin-Miao Liang, and Zong-An Liang.
• Department of Respiratory and Critical Care, West China School of Medicine and West China Hospital, Sichuan University, No.37 Guoxue Alley, Chengdu, 610041, China.
• BMC Pulm Med. 2019 Feb 26; 19 (1): 53.

BackgroundStudies investigating the role of hyperoxia in critically ill patients have reported conflicting results. We did this analysis to reveal the effect of hyperoxia in the patients admitted to the intensive care unit (ICU).MethodsElectronic databases were searched for all the studies exploring the role of hyperoxia in adult patients admitted to ICU. The primary outcome was mortality. Random-effect model was used for quantitative synthesis of the adjusted odds ratio (aOR).ResultsWe identified 24 trials in our final analysis. Statistical heterogeneity was found between hyperoxia and normoxia groups in patients with mechanical ventilation (I2 = 92%, P < 0.01), cardiac arrest(I2 = 63%, P = 0.01), traumatic brain injury (I2 = 85%, P < 0.01) and post cardiac surgery (I2 = 80%, P = 0.03). Compared with normoxia, hyperoxia was associated with higher mortality in overall patients (OR 1.22, 95% CI 1.12~1.33), as well as in the subgroups of cardiac arrest (OR 1.30, 95% CI 1.08~1.57) and extracorporeal life support (ELS) (OR 1.44, 95% CI 1.03~2.02).ConclusionsHyperoxia would lead to higher mortality in critically ill patients especially in the patients with cardiac arrest and ELS.

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