• Xiaohui Wu, Yun Zheng, Xingqiang Gao, Gang Li, and Qiuxue Cao.
• Department of Otolaryngology-Head and Neck Surgery, Xiamen Children's Hospital, Xiamen, China.
• Otolaryngol Head Neck Surg. 2020 Oct 1; 163 (4): 654-661.

ObjectiveTo investigate the potential correlation between Helicobacter pylori infection and otitis media with effusion (OME) risk in children.Data SourcesElectronic databases were searched, including Cochrane Library, PubMed, Embase, China Biology Medicine disc, China Science and Technology Journal Database, Wanfang Database, and China National Knowledge Infrastructure Database.Review MethodsA systematic review and meta-analysis were conducted with Revman 5.3 software. Combined odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate infection-disease association.ResultsIn total, 11 studies from 9 articles regarding H pylori infection and OME risk were enrolled in this meta-analysis. A significant association between H pylori infection and OME was detected for both adenoid samples from the case group (OR, 2.75; 95% CI, 1.43-5.30; P = .002) and middle ear fluid samples from the case group (OR, 4.45; 95% CI, 2.52-7.88; P < .00001). Subgroup analyses suggested a stronger correlation in African and Asian populations.ConclusionThis study indicated the correlation between H pylori infection and increased risk of OME in children, especially in African and Asian populations. Further well-designed studies regarding the white population are strongly recommended in the future.

15 keywords...

hide…