• Clin Med (Lond) · Nov 2020

    The clinical sensitivity of a single SARS-CoV-2 upper respiratory tract RT-PCR test for diagnosing COVID-19 using convalescent antibody as a comparator.

    • Abigail Holborow, Hibo Asad, Lavinia Porter, Poppy Tidswell, Claire Johnston, Ian Blyth, Alice Bone, and Brendan Healy.
    • Public Health Wales Microbiology Department, Swansea, UK.
    • Clin Med (Lond). 2020 Nov 1; 20 (6): e209e211e209-e211.

    AbstractThe clinical false negative rate of reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 on a single upper respiratory tract sample was calculated using convalescent antibody testing as a comparator. The sensitivity in symptomatic individuals was 86.2% (25/29). Of the missed cases, one (3.5%) was detected by repeat RT-PCR, one by CT thorax and two (7.1%) by convalescent antibody. The clinical false negative rate of a single RT-PCR on an upper respiratory tract sample of 14% in symptomatic patients is reassuring when compared to early reports. This report supports a strategy of combining repeat swabbing, use of acute and convalescent antibody testing and CT thorax for COVID-19 diagnosis.© 2020 Royal College of Physicians 2020. All rights reserved.

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