• Ferda Bilgir, Oktay Bilgir, Akan Ozden Yildirim OY http://orcid.org/0000-0002-1215-9305 . Health Sciences University Bozyaka Training and Research Hospital, Department of Interna, and Ismail Demir.
• . Katip Celebi University Ataturk Training and Research Hospital, Department of Allergy and Immunology, Izmir, Turkey.
• Rev Assoc Med Bras (1992). 2020 Aug 1; 66 (8): 1057-1061.

ObjectiveThis study aimed to investigate the effect of propylthiouracil treatment on adhesion molecules in patients with subclinical hyperthyroidism.MethodsIn this study, a total of 168 patients diagnosed with subclinical hyperthyroidism were treated with propylthiouracil for one year. The levels of adhesion molecules, consisting of sICAM-1, sVCAM-1, and sE-Selectin, before and after the treatment were measured and compared. These results were compared with the levels of 148 healthy controls who received a placebo.ResultssICAM-1 levels were significantly higher in subclinical hyperthyroidism patients than in healthy controls (*pa=0.000). sICAM-1 levels were significantly decreased after the treatment (**pb=0.000). Despite this decrease in patients with subclinical hyperthyroidism, it did not decrease to the level of the control group. sVCAM-1 did not change before and after propylthiouracil treatment. The level of sE-selectin was similar to that of the pretreatment control group, but it did not have statistical significance, although it increased after the treatment (**pb=0.004).ConclusionThe sICAM level was significantly higher than the pretreatment values and decreased after the propylthiouracil treatment. However, further studies are needed to reduce the risk of atherosclerosis and cancer in patients with subclinical hyperthyroidism.

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