• Wellington Douglas Rocha Rodrigues, Sarni Roseli Oselka Saccardo ROS http://orcid.org/0000-0001-5839-0871 . Médica assistente e pesquisadora associada, Universidade Federal de São Paulo,, Thais Tobaruela Ortiz Abad, Simone Guerra Lopes da Silva, Fabiola Isabel Suano de Souza, Claudio Arnaldo Len, and Maria Teresa Terreri.
• . Nutricionista, Doutor, Departamento de Pediatria, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
• Rev Assoc Med Bras (1992). 2020 Aug 1; 66 (8): 1093-1099.

AimTo describe the prevalence of dyslipidemia in children and adolescents with autoimmune rheumatic diseases (ARDs), particularly juvenile idiopathic arthritis (JIA), juvenile systemic lupus erythematosus (jSLE), and juvenile dermatomyositis (JDM).MethodsRetrospective cross-sectional study conducted in the pediatric rheumatology outpatient clinic. We evaluated 186 children and adolescents between the ages of 5 and 19 years. The medical records were reviewed for the following data: demographic and clinical features, disease activity, and lipid profile (triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C) and very low density lipoprotein (VLDL-C)). In addition, non-HDL cholesterol was calculated as TC minus HDL-C. The cut-off points proposed by the American Academy of Pediatrics were used to classify the lipid profile.ResultsDyslipidemia was observed in 128 patients (68.8%), the most common being decreased HDL-C (74 patients, 39.8%). In the JIA group there was an association between the systemic subtype and altered LDL-C and NHDL-C, which demonstrated a more atherogenic profile in this subtype (p=0.027 and p=0.017, respectively). Among patients with jSLE, the cumulative corticosteroid dose was associated with an increase in LDL-C (p=0.013) and with a decrease in HDL-C (p=0.022).ConclusionDyslipidemia is common in children and adolescents with ARDs, especially JIA, jSLE, and JDM, and the main alteration in the lipid profile of these patients was decreased HDL-C.

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