• Sibel Gökçay Bek, Berna Üstüner, Necmi Eren, Zeynep Sentürk, and Betül Kalender Gönüllü.
• . Assistant Professor, Nephrology Department, Kocaeli University Hospital, Internal Medicine, İzmit/Kocaeli, Turkey.
• Rev Assoc Med Bras (1992). 2020 Aug 1; 66 (8): 1100-1107.

BackgroundHepcidin is an important regulator of iron homeostasis.ObjectivesThis cross-sectional study was conducted to evaluate the association between hepcidin and components of metabolic syndrome in patients with chronic kidney disease (CKD).Design And Setting103 CKD patients and 59 healthy volunteers were included in the study from the University Hospital.MethodsSerum hepcidin levels were measured by enyzme-linked immunosorbent assay (ELISA) test. As for the study parameters, age, sex, body mass index, renal diseases, serum biochemistry, complete blood count, iron and total iron-binding capacity, ferritin, high-sensitive C-reactive protein (hsCRP), C- reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were evaluated.ResultsThe mean age of the patients was 58.63 ± 11.8 years. Hepcidin level was significantly associated with hypertension and higher uric acid levels (P < 0.05). There was a positive correlation between hepcidin and urea, uric acid, creatinine, ferritin, CRP, ESR, phosphorus, triglyceride, low-density lipoprotein (LDL), proteinuria and albuminuria in 24-hour urine collection. A negative correlation was found between hepcidin and estimated glomerular filtration rate (eGFR), hemoglobin, hematocrit, calcium, 25 OH vitamin D, pH, and bicarbonate levels.ConclusionHepcidin, a well-known hormone regulator of iron metabolism, may play an important role in the pathogenesis of metabolic syndrome in patients with CKD, and further studies might delineate in-depth its potential as a promising early marker in these patients.

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