• Radiology · Dec 2020

    Cardiac MRI of Children with Multisystem Inflammatory Syndrome (MIS-C) Associated with COVID-19: Case Series.

    • Eléonore Blondiaux, Pauline Parisot, Alban Redheuil, Lucile Tzaroukian, Yaël Levy, Chiara Sileo, Aurélie Schnuriger, Mathie Lorrot, Romain Guedj, and Hubert Ducou le Pointe.
    • From the Department of Imaging (E.B., C.S., H.D.l.P.), Pediatric Cardiovascular Unit (P.P.), Neonatal and Pediatric Intensive Care Unit (L.T., Y.L.), Virology Laboratory (A.S.), Department of Pediatrics (M.L.), and Pediatric Emergency Department (R.G.), Hôpital Trousseau-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Hôpital Armand-Trousseau, 26 Avenue du Dr Arnold Netter, 75012 Paris, France; Biomedical Imaging Laboratory, Sorbonne Université, INSERM, CNRS, Paris, France (E.B., A.R.); Department of Cardiovascular and Thoracic Imaging and Interventional Radiology, Institute of Cardiology, Hôpital Pitié-Salpêtrière-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (A.R.); and INSERM Laboratory U955-PHYDES-IMRB-Pharmacological and Therapeutic Strategies for Myocardial Ischemia and Heart Failure, Ecole Vétérinaire, Maisons-Alfort, France (Y.L.).
    • Radiology. 2020 Dec 1; 297 (3): E283-E288.

    AbstractThis case series examines cardiac MRI findings in four children and adolescents admitted to intensive care in April 2020 for multisystem inflammatory syndrome and Kawasaki disease-like features related to coronavirus disease 2019 (COVID-19). Acute myocarditis occurred less than 1 week after onset of fever and gastrointestinal symptoms. Physical examination showed rash and cheilitis or conjunctivitis. All patients recovered after intravenous immunoglobulin therapy. Severe acute respiratory syndrome coronavirus 2 reverse transcription polymerase chain reaction was negative in nasopharyngeal, stool, and respiratory samples and was positive on serology. Cardiac MRI showed diffuse myocardial edema on T2 short tau inversion-recovery sequences and native T1 mapping, with no evidence of late gadolinium enhancement suggestive of replacement fibrosis or focal necrosis. These findings favor postinfectious myocarditis in children and adolescents with COVID-19.© RSNA, 2020.

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