• J. Cardiothorac. Vasc. Anesth. · Nov 2021

    Case Reports

    Activated Coagulation Time and Hepcon Protamine Titration Device to Manage Unfractionated Heparin During Cardiopulmonary Bypass in a Hemophilia A Patient on Emicizumab.

    • James Isaacs, Ian J Welsby, Jacob N Schroder, and Oluwatoyosi A Onwuemene.
    • Department of Medicine, Duke University Medical Center, Durham, NC.
    • J. Cardiothorac. Vasc. Anesth. 2021 Nov 1; 35 (11): 3299-3302.

    AbstractIn the perioperative management of patients with hemophilia A, emicizumab prevents the accurate measurement of common clotting assays, including the activated clotting time (ACT), which is essential for high-dose heparin monitoring during cardiopulmonary bypass surgery. The authors describe the successful perioperative management of a hemophilia A patient on maintenance emicizumab who, following a non-ST myocardial infarction, underwent cardiopulmonary bypass grafting surgery with heparin monitoring using both the ACT and heparin levels from the Hepcon protamine titration device. Postoperatively, the patient was transitioned to recombinant factor VIII replacement therapy. In hemophilia A patients on emicizumab who require heparin titration on cardiopulmonary bypass surgery, the ACT, combined with Hepcon heparin levels, may be used to complete the surgery successfully without excessive bleeding or morbidity.Copyright © 2020 Elsevier Inc. All rights reserved.

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