• J. Thorac. Cardiovasc. Surg. · Mar 2021

    Comparative Study

    Eurolung risk score is associated with long-term survival after curative resection for lung cancer.

    • Alessandro Brunelli, Nilanjan Chaudhuri, Manos Kefaloyannis, Richard Milton, Cecilia Pompili, Peter Tcherveniakov, and Kostas Papagiannopoulos.
    • Department of Thoracic Surgery, St James's University Hospital Bexley Wing, Leeds, United Kingdom. Electronic address: alexit_2000@yahoo.com.
    • J. Thorac. Cardiovasc. Surg. 2021 Mar 1; 161 (3): 776-786.

    ObjectiveThe study objective was to verify whether the Eurolung score was associated with long-term prognosis after lung cancer resection.MethodsA total of 1359 consecutive patients undergoing anatomic lung resection (1136 lobectomies, 103 pneumonectomies, 120 segmentectomies) (2014-2018) were analyzed. The parsimonious aggregate Eurolung2 score was calculated for each patient. Median follow-up was 802 days. Survival distribution was estimated by the Kaplan-Meier method. Cox proportional hazard regression and competing risk regression analyses were used to assess the independent association of Eurolung with overall and disease-specific survival.ResultsPatients were grouped into 4 classes according to their Eurolung scores (A 0-2.5, B 3-5, C 5.5-6.5, D 7-11.5). Most patients were in class A (52%) and B (33%), 8% were in class C, and 7% were in class D. Five-year overall survival decreased across the categories (A: 75%; B: 52%; C: 29%; D: 27%, log rank P < .0001). The score stratified the 3-year overall survival in patients with pT1 (P < .0001) or pT>1 (P < .0001). In addition, the different classes were associated with incremental risk of long-term overall mortality in patients with pN0 (P < .0001) and positive nodes (P = .0005). Cox proportional hazard regression and competing regression analyses showed that Eurolung aggregate score remained significantly associated with overall (hazard ratio, 1.19; P < .0001) and disease-specific survival after adjusting for pT and pN stage (hazard ratio, 1.09; P = .005).ConclusionsEurolung aggregate score was associated with long-term survival after curative resection for cancer. This information may be valuable to inform the shared decision-making process and the multidisciplinary team discussion assisting in the selection of the most appropriate curative treatment in high-risk patients.Copyright © 2020 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

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