• Clin Med (Lond) · Sep 2020

    The diagnostic value of 18F-FDG PET/CT in identifying the causes of fever of unknown origin.

    • Wan Zhu, Wenxia Cao, Xuting Zheng, Xuena Li, Yaming Li, Baiyi Chen, and Jingping Zhang.
    • The First Hospital of China Medical University, Shenyang, China.
    • Clin Med (Lond). 2020 Sep 1; 20 (5): 449453449-453.

    BackgroundThis study investigated the clinical significance of 18F-fluorodeoxyglucose positron emission tomography / computed tomography (18F-FDG PET/CT) in identifying the causes of fever of unknown origin (FUO).MethodsPatients with a fever who received an 18F-FDG PET/CT examination were retrospectively selected. The means of the two groups were compared using an independent-samples t-test.ResultsAmong the 89 included patients, 66 were diagnosed using 18F-FDG PET/CT. The sensitivity, specificity and diagnostic accuracy of 18F-FDG PET/CT for the diagnosis of patients with FUO were 84.5%, 25.8%, and 64.0%, respectively. The detection rates of 18F-FDG PET/CT for neoplastic diseases, infectious diseases and non-infectious inflammatory diseases were 100%, 61.3%, and 75%, respectively. The difference in C-reactive protein (CRP) levels between the two groups was statistically significant.Conclusions18F-FDG PET/CT has great clinical importance in diagnosing and identifying causes of FUO and improves the accuracy of FUO diagnosis when combined with serum CRP levels.© Royal College of Physicians 2020. All rights reserved.

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