• Clin Med (Lond) · Sep 2020

    Acute liver failure.

    • Mohammed A Arshad, Nicholas Murphy, and Mansoor N Bangash.
    • Queen Elizabeth Hospital, Birmingham, UK and Birmingham Liver Failure Research Group, Birmingham, UK mohammed.arshad@uhb.nhs.uk.
    • Clin Med (Lond). 2020 Sep 1; 20 (5): 505508505-508.

    AbstractAcute liver failure is a rare syndrome and is primarily caused by paracetamol toxicity in developed nations. Survival for patients with acute liver failure has steadily improved over the last few decades from approximately 20% to greater than 60%. This marked improvement in survival has been due to a combination of improvements in medical practice and the use of emergency liver transplantation in selected patients. Early recognition and timely initial management in the non-specialist centre can significantly improve outcomes. Patients should be simultaneously discussed with a transplant centre and referred to critical care. Close liaison with transplant centres to ensure timely transfer in deteriorating patients is important.© Royal College of Physicians 2020. All rights reserved.

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