• J Stroke Cerebrovasc Dis · Feb 2018

    Case Reports

    Icatibant as a Potential Treatment of Life-Threatening Alteplase-Induced Angioedema.

    • Edmund Cheong, Lizzie Dodd, William Smith, and Timothy Kleinig.
    • Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia. Electronic address: edmund.cheong@sa.gov.au.
    • J Stroke Cerebrovasc Dis. 2018 Feb 1; 27 (2): e36-e37.

    AbstractSevere orolingual angioedema is a life-threatening complication of alteplase treatment for acute ischemic stroke that occurs during alteplase infusion or in the first 2 hours afterward. Currently, there are no proven therapies, although glucocorticoids, antihistamines, and adrenaline are sometimes used. Intubation is required if significant airway compromise supervenes. The incidence is .2%-5.1%, and risk factors include treatment with angiotensin-converting enzyme inhibitors and total insular infarcts. Here we report a case of alteplase-induced severe angioedema, which resolved briskly following icatibant treatment.Copyright © 2018 National Stroke Association. All rights reserved.

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