• Yunhui Chen, Jiayuan Zhang, Tiane Zhang, Liu Cao, Yanyan You, Chunjiang Zhang, Xinglong Liu, and Qi Zhang.
• Chengdu University of Traditional Chinese Medicine, Jin Niu District.
• Medicine (Baltimore). 2020 Mar 1; 99 (10): e19313e19313.

BackgroundGrowing body of scientific researches in recent years have suggested the promising effect of meditation on improving cognitive impairment of Alzheimer disease (AD) and mild cognitive impairment (MCI). This paper aims to provide a protocol for systematic review to evaluate the efficacy of meditation on cognition performance of patient with AD and MCI.MethodsThe Cochrane Library, PubMed, EMBASE, Web of Science, the Chinese Biological Medicine Database, China National Knowledge Infrastructure, Wanfang database, and VIP information database will be searched systematically and electronically from establishment to March 2020. All published randomized controlled trials related will be included. Assessment of bias risk and data analyses will be implemented by Review Manager (V.5.3.5). The strength of the evidence will be assessed by the Grading of Recommendations Assessment, Development and Evaluation system.ResultsA high-quality synthesis of current evidence of meditation for patient with AD and mild cognitive impairment will be provided in this study.ConclusionThis protocol of systematic review will be helpful for providing evidence of whether meditation is an effective and safe intervention for cognitive impairment of patient with AD and MCI.Ethics And DisseminationEthical approval is unnecessary since this protocol is only for systematic review and does not involve privacy data or conduct an animal experiment. This protocol will be disseminated by a peer-review journal or conference presentation.Systematic Review RegistrationPROSPERO CRD42019145932.

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