• Lijun Shen, Yuming Wang, Xuesong Jiang, Yongcheng Ren, Chengyi Han, and Yongguang Yang.
• Henan Provincial Peoples Hospital, Zhengzhou.
• Medicine (Baltimore). 2020 Mar 1; 99 (10): e19401.

BackgroundThe association of resting heart rate (RHR) and hypertension in adults is unclear. We aimed to perform a meta-analysis of cohort studies to clarify the association.MethodsWe searched PubMed and Embase from their inception to November 3, 2017, for published articles. We used a random effects model to combine study-specific relative risks (RRs) and 95% confidence intervals (CIs). We used restricted cubic spline functions to assess the dose-response relationship.ResultsNine cohort articles (12 independent studies) with 79,399 individuals and more than 26,380 incident cases of hypertension were included. The summary RR for hypertension was 1.09 (95% CI: 1.06-1.13) with each 10 bpm increment in RHR. The cubic spline model suggested that when compared with 55.5 beats per minute, the risk of hypertension significantly increased with increasing levels of RHR (Pnonlinearity = 0.059).ConclusionWe found a linear dose-response association between RHR and incident hypertension in adults.

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