• Guoming Chen, Ruilan Huang, Zhuoxin Huang, Ziyin Chen, Huiping Liu, Jinfeng Wu, Zhiqiang Chen, Tianqi Gao, Hua Xu, and Hai Lan.
• Guangzhou University of Chinese Medicine.
• Medicine (Baltimore). 2020 Sep 18; 99 (38): e22208.

BackgroundAcute lymphoblastic leukemia (ALL) is one of the most commonly seen cancers in children, which mainly relates with inherited genetic variations. Consolidation chemotherapy is usually given to the pediatric ALL patients, however there is no meta-analysis and network analysis conducting the efficacy of the chemotherapy. Therefore, we perform a protocol to assess the efficacy of chemotherapeutics for pediatric ALL.MethodsA literature search for randomized controlled trials about some specific chemotherapy regimens for pediatric ALL will be carried out in 7 electronic databases from their establishment to June 2019: the Cochrane Library, Embase, MEDLINE, the Chinese National Knowledge Infrastructure (CNKI), the Sino Med, the Chinese Scientific Journal Database (VIP) and the Wanfang Database. Complete continuous remission will be measured as primary outcome. Stata 14.0 will be utilized to perform a standard pairwise meta-analysis and the NMA, as well as draw Network Plots of Network Meta.ResultsThis network meta-analysis will evaluate the efficacy of different consolidation chemotherapy regimens.ConclusionThis study will furnish decision-making reference on optimum proposal of chemotherapy regimens for pediatric ALL.Prospero Registration NumberPROSPERO CRD42019134518.

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