• Peng Zhang and Ming Yang.
• Medicine (Baltimore). 2020 Sep 18; 99 (38): e22307.

RationaleSchwannoma is a benign peripheral nerve sheath tumor composed of Schwann cells and caused by genetic mutation or deletion. It rarely occurs in seminal vesicles. The optimal therapic strategy for asymptomatic cases is still unclear.Patient ConcernsA 42-year-old man presented no clinical symptoms. A mass in his left seminal vesicle was found incidentally in a computed tomography scan and transrectal ultrasound-guided biopsy revealed the mass was schwannoma.DiagnosisThe patient was diagnosed as schwannoma of the seminal vesicle with no significant extension to the surrounding tissues.InterventionsThe patient underwent computed tomography or magnetic resonance imaging scans periodically to estimate the alteration of the lesion and further strategy.OutcomesAfter 20-month follow-up, computed tomography scans showed no significant alteration to the lesion and no clinical symptoms were reported by the patient.LessonsConservative strategy might be an effective treatment option for asymptomatic patients with seminal vesical schwannoma. The period of follow-up depends on the size of the tumor.

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