• Kulsoom Bahadur, Aamir Ijaz, Momin Salahuddin, and Aftab Alam.
• Kulsoom Bahadur, MBBS, FCPS. Department of Chemical Pathology and Endocrinology, Resident of Chemical Pathology, Rehman Medical Institute, Peshawar, Pakistan.
• Pak J Med Sci. 2020 Sep 1; 36 (6): 1303-1307.

ObjectiveThis study aims to establish the 99th percentile upper reference limits of high sensitive cardiac troponin I in a healthy Pakistani population.MethodsIt was an Observational cohort study carried out in Department of Chemical Pathology and Endocrinology Rehman Medical Institute Peshawar, over the period of one year (January 2019- December 2019). Total 299 cardio-healthy males and females were interviewed and taken past medical history. Based on history, clinical examination, echocardiogram and laboratory data including results of estimated glomerular filtration rate (eGFR) and N-terminal pro-B-type natriureteric peptide (NT-proBNP), subjects with possible subclinical diseases were excluded. High Sensitive Cardiac Troponin I (hs-cTtrop I) was analysed on Abbot ARCHITECT STAT ci8200 using chemiluminescent immunoassay technique. The 99th percentile upper reference limit (URL) of hs-cTtrop I was determined using a non-parametric statistic, while gender specific results were compared.ResultsIn this study, 178 males (59.5%) and 121 females (40.5%) were included. The median Interquartile ranges (IQR) of age was 57 (11.6) for males and 56 (13) for females. The 99th percentile URL hs-cTtrop I was found to be 33.9 ng/L, while gender specific values were 38.41ng/L and 15.73ng/L for males and females, respectively (p= 0.0045).ConclusionHigh sensitivity cardiac troponin I 99th percentile URL in our study population was found to be 33.9 ng/L with gender specific values being 38.41 ng/L and 15.73ng/L for males and females respectively. Troponin I in males was substantially high in comparison with females.Copyright: © Pakistan Journal of Medical Sciences.

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