• Panminerva medica · Mar 2021

    Review

    Post-transplant consolidation based on combination of lenalidomide and proteasome inhibitors in multiple myeloma.

    • Alessandra Romano, Marco Santoro, Concetta Conticello, Sergio Siragusa, Francesco DI Raimondo, Giovanni Martinelli, and Claudio Cerchione.
    • Department of Surgery and Medical Surgery, University of Catania, Catania, Italy.
    • Panminerva Med. 2021 Mar 1; 63 (1): 13-20.

    AbstractMultiple myeloma (MM) is a hematological malignancy due to uncontrolled proliferation of neoplastic plasma cells in the bone marrow, associated to chromosomal instability and cytogenetic abnormalities, which could have an impact on prognosis. Response to treatment and survival of newly diagnosed myeloma patients is heterogeneous, with median overall survival ranging from two to more than ten years, due to clinical and biological factors. To warrant long-term control of disease, several strategies have been proposed in the last years, including short-term high-dose of treatment, named as consolidation, before maintenance. This review will discuss the role of consolidation in the current myeloma treatment landscape, and further improvements required to optimize tailored front-line therapy.

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