• Annie C Lajoie, Anne-Louise Lafontaine, and Marta Kaminska.
• Respiratory Epidemiology and Clinical Research Unit, McGill University Health Centre, Montreal, Canada.
• Chest. 2021 Feb 1; 159 (2): 818-827.

AbstractThere is increasing interest in the effects of sleep and sleep disturbances on the brain, particularly in relation to aging and neurodegenerative processes. Parkinson disease (PD) is the second most common neurodegenerative disorder, with growing prevalence worldwide. Sleep disorders, including sleep-disordered breathing (SDB), are among the most frequent non-motor manifestations of PD. They can substantially impair quality of life and possibly affect the course of the disease. This article reviews the etiology, implications, and management of sleep disturbances in PD, such as excessive daytime sleepiness, insomnia, restless legs syndrome, rapid eye movement sleep behavior disorder, and SDB. Also briefly explored is the potential role of sleep disorders, including SDB, in the progression of neurodegeneration.Copyright © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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