-
J. Cardiothorac. Vasc. Anesth. · Jul 2021
Case ReportsRole of Tissue Plasminogen Activator for Diffuse Pulmonary Microemboli in Coronavirus Disease 2019 Patient.
- Samit Ghia, Himani Bhatt, and Michael Lazar.
- Mount Sinai Morningside and West Hospitals, Icahn School of Medicine, New York, NY. Electronic address: samit.ghia@mountsinai.org.
- J. Cardiothorac. Vasc. Anesth. 2021 Jul 1; 35 (7): 2137-2139.
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related hypercoagulability has been of great interest in the pathophysiology of coronavirus disease 2019 (COVID-19). Many patients have clinical findings of dead-space ventilation, similar to pulmonary embolism. Herein, a patient who presented with COVID-19 pneumonia and whose condition rapidly deteriorated to respiratory failure requiring intubation is described. Tissue plasminogen activator (tPA) was administered because of concern of pulmonary microemboli, with improvement of respiratory status and extubation within 24 hours. Patients with COVID-19 infection have an increased risk of thrombus formation,1 and the administration of tPA may benefit these patients by immediately lysing diffuse thrombi and improving gas exchange.Copyright © 2020 Elsevier Inc. All rights reserved.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..