• Yenho You, Jin Hong Min, Jung Soo Park, Yong Chul Cho, Won Joon Jeong, Hong Joon Ahn, Changshin Kang, In Ho Lee, Chan Kang, Byung Kook Lee, and Chun Song Youn.
• Department of Emergency Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea.
• Ther Hypothermia Temp Manag. 2021 Jun 1; 11 (2): 110-116.

AbstractWe aimed to investigate the prognostic performance of the proportion of cerebrospinal fluid volume (pCSV) using brain apparent diffusion coefficient-magnetic resonance imaging (ADC-MRI) in cardiac arrest (CA) survivors. This retrospective single-cohort study comprised adult comatose CA survivors who underwent brain MRI and targeted temperature management (TTM) from March 2018 to October 2019. We calculated pCSV (pCSV0 and pCSV72 within 6 and 72 hours after return of spontaneous circulation, respectively) using an automated quantitative analysis program. The difference between pCSV0 and pCSV72 was defined as the pCSVd. Neurologic outcome 3 months after CA was assessed with the Cerebral Performance Category scale and dichotomized as good (1 or 2) or poor (3-5). Of the 73 patients included, 44 (60.3%) had a poor neurological outcome. Patients with poor outcome had significantly lower pCSV at baseline and at 72 hours, and a negative change in pCSV over time. The prognostic performance of pCSV72 and pCSVd was significantly higher compared with pCSV0 (all p < 0.001). The pCSVd showed excellent area under the curve values (0.96; 95% confidence interval 0.85-0.99) and highest sensitivity (95%) at 100% specificity. pCSV on brain ADC-MRI was associated with 3-month neurologic outcome in CA survivors. The pCSVd is a highly predictive and sensitive marker of 3-month poor neurological outcome in CA survivors treated with TTM. Multicenter prospective studies are required to determine the generalizability of these results.

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