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Review Case Reports
[Low titer cold agglutinin disease due to anti-HI antibody and a review of this disease in Japan].
- H Yamauchi, K Iwamasa, K Yanagisawa, T Tamai, M Yasukawa, and S Fujita.
- First Department of Internal Medicine, Ehime University.
- Rinsho Ketsueki. 1995 Apr 1; 36 (4): 334-8.
AbstractA 79 year-old Japanese man was admitted because of brownish urine and Raynaud phenomenon. Laboratory data showed mild anemia with reticulocytosis, positive direct Coombs test against anti-C3, elevated level of lactate dehydrogenase, undetectable level of serum haptoglobin and low titer of cold agglutinin (1:256 at 4 degrees C), the immunoglobulin subclass of which was IgM. Cold agglutinin disease is usually associated with very high levels of cold agglutinins, the specificity of which is anti-I. This case had low titer cold agglutinin disease due to anti-HI cold agglutinin.
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