• Medicina clinica · Oct 2020

    Incidence of malignancy in a Spanish cohort of patients infected by the human immunodeficiency virus.

    • Esperanza Cañas-Ruano, Mario Martín-Castillo, Berta Raventós, Joaquín Burgos, Adrià Curran, Jordi Navarro, Jorge García, Paula Suanzes, Esteban Ribera, and Vicenç Falcó.
    • Vall d'Hebron Institut de Recerca, Barcelona, España; Servicio de Enfermedades Infecciosas, Hospital Universitario Vall d'Hebron, Barcelona, España. Electronic address: mcanas@vhebron.net.
    • Med Clin (Barc). 2020 Oct 9; 155 (7): 288-294.

    IntroductionA higher incidence of malignancies has been described in patients with HIV infection compared to the general population.Patients And MethodsObservational retrospective study in patients with HIV infection followed up at the Vall d'Hebron University Hospital (Barcelona, Spain) between 2009 and 2017. The objective of this research was to estimate the incidence of malignancies in HIV patients and their surveillance. Age and sex-adjusted incidence was compared to the incidence calculated by the Spanish Cancer Registry network (REDECAN) in 2015.ResultsWe included 2,773 patients (41,238 patients-year). Two hundred and eleven malignancies were diagnosed in 182 patients. Non-AIDS defining cancers accounted for 78.2% of the malignancies. The global incidence of cancer was 485 cases per 100,000 person-years. Twenty-year mortality rate was 31.2% in patients with cancer and 7.8% in patients without cancer. In men, adjusted for age, the incidence of malignancies was higher than the incidence in the general population (978.4 vs. 641 cases per 100,000 person-years, P<.001). The most common malignancies in men were lung cancer, Kaposi sarcoma and Hodgkin lymphoma. In women, the incidence of malignancies was not higher than in the general population (340.6 vs. 404.7 cases per 100,000 person-years, P=.27). The most common malignancies among women were lung cancer, head and neck cancer, cervical cancer and Hodgkin's lymphoma.ConclusionsMen with HIV infection showed a statistically significant higher incidence of malignancies compared to the general Spanish population. Lung cancer was the most common non-AIDS defining cancer.Copyright © 2019. Published by Elsevier España, S.L.U.

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