• mSphere · Jul 2020

    Human Infection Challenge Studies: a Test for the Social Value Criterion of Research Ethics.

    • Nicholas G Evans.
    • Department of Philosophy, University of Massachusetts Lowell, Lowell, Massachusetts, USA Nicholas_evans@uml.edu.
    • mSphere. 2020 Jul 15; 5 (4).

    AbstractHuman infection challenge studies involving the intentional infection of research participants with a disease-causing agent have recently been suggested as a means to speed up the search for a vaccine for the ongoing coronavirus disease 2019 (COVID-19) outbreak. Calls for challenge studies, however, rely on the expected social value of these studies. This value represents more than the simple possibility that a successful study will lead to the rapid development and dissemination of vaccines but also some expectation that this will actually occur. I show how this expectation may not be realistic in the current political moment and offer potential ways to make sure that any challenge trials that arise actually achieve their goals.Copyright © 2020 Evans.

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