• Immunotherapy · Mar 2017

    Review

    Anti-CTLA-4 therapy for malignant mesothelioma.

    • Alice Guazzelli, Emyr Bakker, Marija Krstic-Demonacos, Michael P Lisanti, Federica Sotgia, and Luciano Mutti.
    • Biomedical Research Centre, School of Environment & Life Sciences, University of Salford, Salford, UK.
    • Immunotherapy. 2017 Mar 1; 9 (3): 273-280.

    AbstractImmunotherapy is an emerging therapeutic strategy with a promising clinical outcome in some solid tumors, particularly metastatic melanoma. One approach to immunotherapy is immune checkpoint inhibitors, such as blockage of CTLA-4 and PD-1/PD-L1. This special report aims to describe the state of clinical trials of tremelimumab in patients with unresectable malignant mesothelioma (MM) in particular with regard to the clinical efficacy, safety and tolerability. Criticism and perspective of this treatment are also discussed. Biological and clinical considerations rule out the use of tremelimumab as single agent for MM and, more generally, the use of immune checkpoint inhibitors for MM is still largely questionable and not supported by evidences.

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