• J. Hosp. Infect. · Dec 2015

    Randomized Controlled Trial

    Reduced occurrence of ventilator-associated pneumonia after cardiac surgery using preoperative 0.2% chlorhexidine oral rinse: results from a single-centre single-blinded randomized trial.

    • Y J Lin, L Xu, X Z Huang, F Jiang, S L Li, F Lin, Q Y Ye, M L Chen, and J L Lin.
    • Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China. Electronic address: fjxhlyj@163.com.
    • J. Hosp. Infect. 2015 Dec 1; 91 (4): 362-6.

    AbstractSince mechanical ventilation after cardiac surgery increases the risk of ventilator-associated pneumonia (VAP), we conducted a prospective randomized controlled trial to investigate the effect of preoperative 0.2% chlorhexidine on postoperative VAP. Ninety-four patients scheduled for heart surgery were randomized to a chlorhexidine group (N = 47) or control (saline) group (N = 47). On the day before surgery, patients gargled three times with 0.2% chlorhexidine or saline 30 min after each meal and 5 min after teeth brushing at bedtime. VAP occurred in 8.5% of the chlorhexidine group and in 23.4% of the controls. Preoperative chlorhexidine mouthwash reduced the incidence of postoperative VAP significantly.Copyright © 2015 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

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