• J Eur Acad Dermatol Venereol · Apr 2006

    Case Reports

    Minocycline-induced cutaneous hyperpigmentation: confocal laser scanning microscope analysis.

    • R P Dodiuk-Gad, H M de Morentin, J Schafer, A Harel, M Neudorfer, F Misonzhnik, G Gitstein, D Rozenman, E Tur, and S Brenner.
    • Department of Dermatology, Ha'emek Medical Center, Afula, Israel.
    • J Eur Acad Dermatol Venereol. 2006 Apr 1; 20 (4): 435-9.

    BackgroundMinocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation.ObjectiveTo investigate whether the fluorescence can be detected in other types of minocycline-induced cutaneous hyperpigmentation, and to study the possible mechanisms.MethodsBiopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning Microscope (CLSM).ResultsA yellow-green fluorescence was observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline-induced cutaneous hyperpigmentation. No fluorescence was detected in the non-pigmented skin.ConclusionMinocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline-induced cutaneous hyperpigmentation.

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