• Lourdes Mateu, Aina Teniente-Serra, Gemma Rocamora, Antoni Marin-Muñiz, Noemi Pàrraga, Irma Casas, Esteban Reynaga, Nieves Sopena, Miguel Sabria, María Luisa Pedro-Botet, and los miembros del Comité de Inmunodeficiencias Primarias del Hospital Germans Trias i Pujol.
• Servicio de Enfermedades Infecciosas, Hospital Germans Trias i Pujol, Badalona, Barcelona, España; Universitat Autònoma Barcelona, Departamento de Medicina, Barcelona, España; CIBER enfermedades respiratorias, Madrid, España; Institut de Recerca Germans Trias i Pujol, Barcelona, España.
• Med Clin (Barc). 2021 Mar 26; 156 (6): 270-276.

Background And ObjectivesPredominantly antibody deficiencies are the most prevalent primary immunodeficiency (PID) in adults. These are rare diseases difficult to diagnose. Therefore, they are diagnosed late. This study aims to evaluate whether an awareness campaign of PIDs among physicians is associated with an increase in number of diagnoses, a reduction in diagnostic delay and diagnosis at earlier stages.Patients And MethodsA single centre, interventional, quasi-experimental study was designed that included 2 periods, period 1 pre-intervention (1986-2008) and period 2 post-intervention (2009-2018). A descriptive comparative study of variables was carried out in both periods.Results116 patients were included [27 (23.3%) in period 1 and 89 (76.7%) in period 2]. The incidence rate increased significantly (0.204 and 1.236/100,000habs./year; P < 0.05), the diagnosis delay tended to be lower (4 vs. 3.73 years). The reasons for diagnostic suspicion were diverse and the burden disease at diagnosis (expressed by bronchiectasis, altered spirometry, ability to generate antibodies by thymus-independent mechanism and need for substitute treatment) tended to decrease in period 2.ConclusionsGiven the potentially serious complications of patients with late diagnosis of PIDs, it is necessary to create specialized multidisciplinary units, to unify assistance protocols and to design interventions to increase the knowledge of these entities.Copyright © 2020 Elsevier España, S.L.U. All rights reserved.

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