• Dursun Türköz, Aytaç Türköz, Mehmet Emin Önger, and Enis Kuruoğlu.
• Department of Neurosurgery, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey
• Turk J Med Sci. 2021 Feb 26; 51 (1): 375-381.

Background/AimThis study’s aim was to investigate the effects of thymoquinone, which is the essential bioactive component of the volatile oil of Nigella sativa on the peridural fibrosis in rats following laminectomy.Materials And MethodsTwenty female Wistar Albino rats were used in our study. The rats were randomly divided into 2 groups: Sham and Surgery + Thymoquinone. Both groups underwent laminectomy at L1 under general anesthesia. The Sham group was not subjected to any drug application. The 2nd group was treated with intraperitoneal 10-mg/kg thymoquinone once per day for a period of 28 days, following the same surgical procedure. All of the group specimens were sacrificed after 4 weeks, and the laminectomy area was examined in terms of new bone volume, capillary volume, and fibrosis volume using stereological approaches.ResultsStatistically significant differences were found between the Sham and Surgery + Thymoquinone groups in terms of new bone volume (P = 0.01), capillary volume (P = 0.01), and fibrosis volume (P < 0.001). It was noted that Thymoquinone caused a significant increase in new bone volume, vascular volume and, a significant decrease in fibrosis volume.ConclusionThe results of our study indicate that thymoquinone is effective in decreasing peridural fibrosis when applied to a laminectomy model.This work is licensed under a Creative Commons Attribution 4.0 International License.

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