• Ce Tang, Lianghong Ye, Zhipeng Hu, Wenxiang Wang, Tingting Kuang, Gang Fan, Yi Zhang, XiuHua Liu, and Maoyi Yang.
• Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu.
• Medicine (Baltimore). 2020 Sep 25; 99 (39): e22224.

BackgroundRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by erosion of joints and surrounding tissues. RA not only causes the decline of patients' physical function and quality of life, but also brings huge economic burden to patients' families and society. Total glucosides of paeony (TGP) is commonly used in treating RA in China. At present, there are many clinical reports about this medicine, but these reports have their own flaws. Therefore, there is an urgent need for systematic review and meta-analysis of the existing clinical evidence.Methods And AnalysisLiterature search will be carried out in 6 databases, and the literatures will be screened according to the inclusion and exclusion criteria. The clinical effective rate will be taken as primary outcome. Serum rheumatoid factor, C-reactive protein, erythrocyte sedimentation rate, Western Ontario and McMaster before and after treatment and adverse effects will be secondary outcomes. The heterogeneity of the study will be examined by χ and I test. To identify the source of heterogeneity, subgroup analysis will be carried out. The sensitivity test will be conducted investigate the stability of results. Funnel plot and Egger test will be used to evaluate publication bias. Finally, the quality of evidence will be summarized.ResultsThe results will be published in peer-reviewed journals.ConclusionsThis study will systematically evaluate the efficacy of TGP in the treatment of RA. The results of this study can better guide clinical practice.Osf Registration NumberDOI 10.17605/OSF.IO/85QVF.

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