• Yehao Luo, Donghan Xu, Zhiyong Cao, Qiuxia Chen, Lizhen Wang, Gang Fang, and Yuzhou Pang.
• Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi Province.
• Medicine (Baltimore). 2020 Sep 25; 99 (39): e22264e22264.

BackgroundRheumatoid arthritis (RA) is a common chronic inflammatory autoimmune disease, which can lead to joint destruction, dysfunction, finally deformity. Currently, Western medicine treats it with disease-modifying antireheumatic drugs, NSAIDs, glucocorticoid, biological agents, etc, which can induce adverse drug reactions. And now, as an important mean of treating RA, Zhuang medicine has been widely used in clinics, and has achieved significant efficacy.Methods And AnalysisThe following databases will be searched for relevant information before July 2020: PubMed, Embase, Cochrane Library, Web of Science, and China National Knowledge Infrastructure.Major Resultslevels of C-reactive protein, erythrocyte sedimentation rate, Rheumatoid factor. Secondary results: morning stiffness time, range of motion, arthralgia, joint tenderness index, joint swelling index, total effective rate, adverse event. Data will be collected independently by 2 researchers, and the risk of bias in meta analysis will be evaluated according to "Cochrane Handbook for Systematic Reviews of Interventions". All data analysis will be conducted using Review Manager V.5.3. and Stata V.12.0.ResultsThe curative effect and safety of traditional therapies of Zhuang Medicine treatment for RA patients will be evaluated systematically.ConclusionThe systematic review of this study will summarize the currently published evidence of traditional therapies of Zhuang Medicine treatment for RA to further guide its promotion and application.Open Science Framework (OSF) registration number: https://osf.io/c4xv3/.

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