• Pak J Med Sci · Nov 2019

    Emerging resistance of van genotype in enterococci: A potential menace for therapeutic failure.

    • Hasan Ejaz.
    • Dr. Hasan Ejaz, PhD, Department of Clinical Laboratory Sciences, CAMS, Jouf University, Sakaka, Saudi Arabia.
    • Pak J Med Sci. 2019 Nov 1; 35 (6): 1659-1663.

    ObjectivesEmerging cases of vancomycin-resistant enterococci (VRE) are detrimental for the patients. The current study aimed to ascertain the occurrence of VRE, their antibiogram and the van genotype responsible for vancomycin resistance.MethodsA total number of 2,958 clinical specimens were processed at Microbiology Department of the Alrazi Health Care, Lahore during the one year (2016-2017) using microbiological culture media, biochemical and serology. Antibiogram of enterococcal strains was performed using disc diffusion and E-test. ATCC Enterococcus faecalis 29212 was used as a quality control strain. The detection of van genotypes was accomplished by multiplex PCR assay.ResultsOut of the 147 enterococci, 139 (94.6%) were E. faecalis, and 8 (5.4%) were E. faecium. Statistically significant associations of urine (p < 0.001), pus (p < 0.001) and wound swabs (p = 0.001) were observed with E. faecalis. A significant correlation of enterococcal infections (p = 0.05) was seen with female patients. Four (2.9%) strains of E. faecalis found to be VRE with vanB (75%) and vanA (25%) genotypes.ConclusionThe emerging strains of VRE (vanB and vanA genotype) in the current study are a potential menace for therapeutic failure, which left the physicians with only linezolid as a therapeutic option.Copyright: © Pakistan Journal of Medical Sciences.

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