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- Alex J Thompson and Jacinta A Holmes.
- Department of Gastroenterology, St Vincent's Hospital; University of Melbourne, Melbourne.
- Aust Prescr. 2015 Dec 1; 38 (6): 191-7.
AbstractChronic hepatitis C infection causes cirrhosis, liver failure and hepatocellular carcinoma, and is the most common indication for liver transplantation. Hepatitis C is curable and complications can be prevented. Until recently, treatment regimens involved peginterferon alfa. Although effective, their widespread use is limited by treatment-related toxicity. A number of direct-acting drugs for hepatitis C, such as sofosbuvir, have recently been developed and target multiple steps in the viral life cycle. These drugs are used in combination in interferon-free regimens. Short courses are highly effective with minimal toxicity.
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